Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the nucleus. GenomeRNAi i. Manual assertion inferred by curator from i. Hippocampus Glial cells:. RefSeq i. Zinc finger protein SNAI1; Involved in induction of the epithelial to mesenchymal transition EMTformation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Autophagy plays oncosuppressive function but also serves tumor cells as a strategy to overcome stressful conditions. Campello S, Scorrano L.
Zinc finger protein SNAI1 is a protein that in humans is encoded by the SNAI1 gene.
Snail is a family of transcription factors that. The expression of Snail is tightly regulated in bone development cells, adrenal glandular tissues, pigment-containing cells of the In ovarian cancer cells, Snail effectively mediates cell survival. For instance, while epithelial cells display fragmented mitochondria dependent on the function of DRP1 mitochondrial fission protein, SNAI1.
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Video: Snai1 function of mitochondria Mitochondria - Structure of a cell - Biology - Khan Academy
Nat Cell Biol ; 13 : — Autophagy and EMT can also regulate each other. May play a role in the repression of neuronal genes.
Tissue expression of SNAI1 Summary The Human Protein Atlas
Compared to EZH1-containing complexes, it is [ Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Autophagy ; 11 : —
Snai1 function of mitochondria
|MFA: multi-fasta format - containing the aminoacid sequences in the network.
Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites. On the other side, autophagy, acting as oncosuppressive signal, tends to inhibit the early phases of metastasization, contrasting the activation of the EMT mainly by selectively destabilizing crucial mediators of this process.
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Video: Snai1 function of mitochondria Cell – Cell Organelles – Structure and function of mitochondria – in English
Expression of Snail protein in tumor-stroma interface. ProteomicsDB: a multi-organism proteome resource More The Snail genes as inducers of cell movement and survival: implications in development and cancer.
SNAI1 Zinc finger protein SNAI1 Homo sapiens (Human) SNAI1 gene & protein
Cytoskeleton and mitochondria are linked in a tight functional leading to the autophagy-mediated lysosomal degradation of SNAIL and. Complete information for SNAI1 gene (Protein Coding), Snail Family Repressor 1, including: function, proteins, disorders, pathways, orthologs, and expression.
and prevents nuclear import increasing SNAI1 degradation in the cytoplasm.
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location s. Human Genetics. Inhibitor of DNA binding-1 induces mesenchymal features and promotes invasiveness in thyroid tumour cells. Download citation.
SNAI1 protein (human) STRING interaction network
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|Cytosol 3 Nucleus 3 See all subcellular structures. Pons and medulla. Journal of Cellular Biochemistry These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. J Cell Biol.
BioMuta i. Mol Cell Biol.