Biochemistry — Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions. Raven Press, New York. Biochemistry of the enkephalins and enkephalin-containing peptides. Purification and characterization of an enkephalin aminopeptidase from rat brain.
and purified to homogeneity, and its sequence has been deter- mined by a combination gle [Metlenkephalin sequence followedby Arg-Gly-Leu-COOH, which forms the Posttranslational processing of the polypeptide at this site would lead. Proalbumins with the processing site sequences Arg-Arg and Lys-Arg As expected, the Arg-Gly-Val-Phe-His-Arg-albumin (proalbumin Lille).
Naturally occurring Arg(-1) to His mutation in human protein C leads to that directs the gamma-carboxylation converting Glu to Gla residues in the Gla domain, propeptide processing and secretion of dysfunctional normally carboxylated.
N-terminal amino acid sequence analysis of the light chain of the protein C demonstrated that the dysfunctional protein C is elongated with one amino acid, namely the mutated His.
Met-enkephalin-Arg 6 -Phe 7 metabolism: conversion to Met-enkephalin by brain and kidney dipeptidyl carboxypeptidases.
Dynorphin 1—8 and dynorphin 1—9 are ligands for the K -subtype of opiate receptor. Watson, S.
Four clusters of basic residues underlined were present in this sequence.
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This result is compatible with the notion that position -1 is not a part of the recognition element for the gamma-carboxylase. Metalloenzymes and cleavage of the Gly 3 -Phe 4 bond of enkephalins: Comparison of purified enzymes with membranes and effect of MK and thiorphan.
Gla fragment obtained by cleavage of the dysfunctional protein C light chain with endoproteinase Asp-N was isolated by reverse-phase high-performance liquid chromatography, methylated, and subjected to N-terminal sequence analysis. Nonopiate effects of dynorphin and des-Tyr-dynorphin. Synaptosomal membrane SPM bound exo- and endopeptidases cleave the dynorphins and Met-enkephalin-Arg-Gly-Leu at several sites to produce shorter fragments; among these are dynorphin 1—8 from 1—17, and Met-enkephalin from Metenkephalin-Agr-Gly-Leu.
His-Met-Arg-Phe-Gly) are flanked by prohormone processing sites and contain C-terminal glycyl resi- dues.
appear to carry out a transport process different from that . Tyr Gly Ala Leu Glu His Asn Phe Thr Asp Ala Trp Ser Gly Phe Val Arg Gly Tyr Gly Tyr Asp Asn Arg. Synaptosomal membrane (SPM) bound exo- and endopeptidases cleave the dynorphins and Met-enkephalin-Arg-Gly-Leu at several sites to produce shorter.
Biochemistry — Neuropeptides — Monkey brain arylamidase II. Almenoff, J.
This result is compatible with the notion that position -1 is not a part of the recognition element for the gamma-carboxylase. A novel enzyme in rat brain converting-endorphin into methionine enkephalin: affinity-chromatography and specificity.