Sign up for our Email Newsletters. Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations. Gynecol Oncol ; 91 :9— Glenn McCluggage Modern Pathology Uterine leiomyomas with bizarre nuclei: a clinicopathologic study of 59 cases.
Caldesmon binds calcium, calmodulin, tropomyosin and actin and regulates smooth muscle contraction (Int J Biochem Cell Biol ;). Pathology Outlines Conference Search. December 3 - 7,California Society of Pathologists: CSP 72nd Annual Meeting, Hyatt Regency San Francisco. Modern Pathology volume 29, pages S–S () | Download Citation used as a part of a panel of antibodies that also includes desmin and h-caldesmon.
Immunohistochemistry for Diagnosis of Metastatic Carcinomas of Unknown Primary Site
. The tumor shows irregular outlines associated with individual foci of necrosis and Nature Careers · Nature Conferences · Nature events.
Thus, inquiring about the clinical history, especially about progestin intake may be very helpful in the correct interpretation of a uterine smooth muscle tumor.
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Am J Surg Pathol ; 19 — Apoplectic leiomyoma is also designated as hemorrhagic cellular leiomyoma, as this term appropriately emphasizes the multifocal nature of the hemorrhagic foci on gross and microscopic examination. Myxoid smooth muscle tumors.
Rarely, myxoid change can occur in the myometrium in patients with lupus erythematosus with secondary muscle hypertrophy, termed as "myxoidosis" 82 or neurofibromatosis, type I 83 forming variably circumscribed nodules. Among mesenchymal tumors of the uterus, smooth muscle neoplasms are most common.
from the international society of urologic pathology consensus conference. Abstracts and Case Studies From the College of American Pathologists The meeting will take place at the Wynn-Encore Hotels in Las Vegas, Nevada.
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HMB, Melan-A, S, caldesmon, CD34, and myogenin were negative. including multiple germinal cells and cilia outlining their periphery (Figure 66).
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SECTION III: REGULAR AND SPECIAL FEATURES: Orthopaedic • Radiology • Pathology Conference. SDC Back to Top | Article Outline. Immunohistochemical staining with alpha smooth muscle actin, calponin, and. The frozen-section pathology report demonstrated tumor-free margins for all four nodular masses.
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy.
The differential diagnosis may be confounded if the latter is associated with a high-grade endometrial stromal sarcoma. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Thus, sampling as well as exclusion of other entities in the differential diagnosis, is key.
In general, to render a diagnosis of malignancy in smooth muscle tumors of the uterus is relatively straightforward as leiomyosarcomas usually display marked nuclear atypia, high mitotic rate, and tumor cell necrosis.
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|Int J Gynecol Pathol ; 7 — Most spindled and epithelioid leiomyosarcomas are hypercellular but they can be normo- or hypocellular, the latter being more common in the myxoid variant where cells are embedded in an abundant weakly basophilic matrix, strongly positive with Alcian blue and colloidal iron.
EpsteinF. The tumor is more positive for Melan A in epithelioid areas c ; CathepsinK shows extensive positivity d. Dedifferentiated leiomyosarcoma: clinicopathological analysis of 18 cases.
Uterine tumors resembling ovarian sex cord tumors: an update.