ProteomeXchange provides globally coordinated proteomics data submission and dissemination. Cancer Detect. The enriched terms of neoplastic islands are associated with a hallmark of cancer, as the ability to reprogram the metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells 36 View Articles. Untreated HepG2 cells C determined baseline expression. Multivariate analysis of the mineral content of raw and cooked okra Abelmoschus esculentus L. Otolaryngology—Head and Neck Surgery
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Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity SpringerLink
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In this study, we used a murine model of APAP poisoning to show that activation of several P2 receptors is detrimental during liver injury progression. Zhang, J. CAS Google Scholar We performed a repeated cross-validation rep. To validate our findings in humans, we investigated the profile of purinergic receptors expression in patients diagnosed with drug-induced acute hepatitis.
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Otolaryngology—Head and Neck Surgery Mol Microbiol. Low CSTB levels have previously been correlated with a shorter disease-free survival rate in breast cancer ProteomeXchange provides globally coordinated proteomics data submission and dissemination.
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Show more authors. Ariane Agnes Corradi. Federal University of. Luciana Mourão.
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After different time-points, mice were anesthetized and euthanized for blood serumliver, BAL bronchial-alveolar lavage and lung harvesting.
It is worth taking into consideration that although we observed P2 receptor upregulation in HepG2 cells following APAP challenge, it is conceivable that purinergic signaling in other cell types i. EMBO J. The whole human proteome Gene Ontology GO annotation file was used as a reference set. The lower clustering identified in neoplastic islands compared with tumor stroma may be associated with different abilities to extract proteins from FFPE tissues and may also reflect the intrinsic tumor heterogeneity 712as OSCCs are known for their biological variability, which leads to specific clinical behaviors, i.
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Mice were imaged by sequential laser scans 2. P2X7but rather mediated by different P2 receptors subfamilies, suggesting that larger spectrum inhibition might be necessary to promote appreciable cytoprotection. Acknowledgements Authors would like to Dr. In fact, despite the hepatoprotection and the reduced levels of circulating cytokines promoted by apyrase treatment, DAMPs released probably from remote injury were sufficient to support lung inflammation [ 17 ].
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A Gomes, F Santos, W Lira, B Gomes, SR Carvalho Vasconcelos, Antônio Silva, Ariane Sinimbú, Elder Silva, Maurício Ronny, Wallace Lira, Sandro Oliveira.
MP4 KB. These effects may be explained by ATP ability to directly cause intracellular ionic dysregulation in acetaminophen-treated cells.
Carnielli, C. Positive staining in muscle was detected for MB.
So far, the damage exerted by increased extracellular concentrations of ATP has been solely attributed to indirect, inflammatory effects over immune cells [ 1126 ]. IHC was the first method of choice because of its broad applications in clinical practice and ability to provide results for patient postoperative management decisions Korn, Sergio L.